Publications

Pho H, Hernandez AB, Arias RS, Leitner EB, Van Kooten S, Kirkness JP, Schneider H, Smith PL, Polotsky VY, Schwartz AR. The effect of leptin replacement on sleep-disordered breathing in the leptin-deficient ob/ob mouse. J Appl Physiol (1985). 2016 Jan 1;120(1):78-86. doi: 10.1152/japplphysiol.00494.2015. Epub 2015 Oct 15. PMID: 26472867

Fleury Curado T, Pho H, Berger S, Caballero-Eraso C, Shin MK, Sennes LU, Pham L, Schwartz AR, Polotsky VY. Sleep-disordered breathing in C57BL/6J mice with diet-induced obesity. Sleep. 2018 Aug 1;41(8):zsy089. doi: 10.1093/sleep/zsy089. PMID: 29767787

Berger S, Pho H, Fleury-Curado T, Bevans-Fonti S, Younas H, Shin MK, Jun JC, Anokye-Danso F, Ahima RS, Enquist LW, Mendelowitz D, Schwartz AR, Polotsky VY. Intranasal Leptin Relieves Sleep-disordered Breathing in Mice with Diet-induced Obesity. Am J Respir Crit Care Med. 2019 Mar 15;199(6):773-783. doi: 10.1164/rccm.201805-0879OC. PMID: 30309268

Shin M-K, Kim LJ, Caballero-Eraso C, and Polotsky VY. Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing. J Vis Exp. 2019. Oct 25; (152). doi: 10.379/60298. PMID: 31710041.

Shin M-K, Caballero Eraso C, Mu Y-P, Gu C, Yeung BHY., Kim LJ, Liu X-R, Wu Z-J, Paudel O, Pichard LE, , Shirahata M, Tang W-Y, Sham JSK, and Polotsky VY.  Leptin induces hypertension acting on transient receptor potential melastatin 7 (Trpm7) channel in the carotid body. Circ Res. 2019. Nov 8;125(11):989-1002. PMID: 31710041.

Editorial: Zheng F, Mu S., Rusch NJ. Leptin activates Trpm7 channels in the carotid body as a mechanism of obesity-related hypertension. Circ Res. 2019. Nov 8;125(11):1003-1005.

Dergacheva O, Fleury-Curado T, Polotsky VY, Kay M, Jain V, Mendelowitz D. GABA and glycine neurons from the ventral medullary region inhibit hypoglossal motoneurons. Sleep. 2020 Jun 15;43(6):zsz301. doi: 10.1093/sleep/zsz301.

Gu C, Brereton N,  Schweitzer A, Cotter M, Duan D, Børsheim E, Wolfe RR, Pham LV, Polotsky VY, Jun JC. Metabolic Effects of Late Dinner in Healthy Volunteers - A Randomized Crossover Clinical Trial. J Clin Endocrinol Metab. 2020 Aug 1;105(8):2789-802. doi: 10.1210/clinem/dgaa354. PMID: 32525525

Freire C, Pho H, Kim LJ, Wang X,  Dyavanapalli J, Streeter SR, Fleury-Curado T, Sennes LU, Mendelowitz D, Polotsky VY.  Intranasal leptin prevents opioid induced respiratory depression in obese mice. Am J Respir Cell Mol Biol. 2020 Oct;63(4):502-509. doi: 10.1165/rcmb.2020-0117OC. PMID: 32603263

Editorial: Prasad B, Chowdhuri S. Will Intranasal Leptin Mitigate Opioid-induced Sleep-disordered Breathing? Am J Respir Cell Mol Biol. 2020 Oct;63(4):410-412.

Fleury-Curado T, Pho H, Freire C, Amorim MR, Bonaventura J, Kim LJ, Lee R, Cabassa ME, Streeter SR, Branco LG, Sennes LU, Fishbein K, Spencer RG, Schwartz AR, Brennick MJ, Michaelides M, Fuller DD, Polotsky VY. DREADD approach to treatment of sleep disordered breathing. Am J Respir Crit Care Med. 2021 Jan 1;203(1):102-110. doi: 10.1164/rccm.202002-0321OC. PMID: 3267307598.

Editorial: Veasey S. An X on the map for Sleep Apnea’s Holy Grail: Drug Therapy. Am J Respir Crit Care Med. 2021 Jan 1;203(1):10-11.

Pho H, Berger S, Freire C, Kim LJ, Shin M-K, Streeter SR, Hosamane N, Cabassa ME, Anokye-Danso F, Dergacheva O, Amorim M, Fleury-Curado T, Jun JJ, Schwartz AR, Ahima RS, Mendelowitz D, Polotsky VY. Leptin receptor expression in the dorsomedial hypothalamus stimulates breathing during NREM sleep in db/db mice. Sleep. 2021 Feb 24;zsab046. doi: 10.1093/sleep/zsab046. Online ahead of print. PMID: 33624805.

Editorial: Conde S. Leptin and dorsomedial hypothalamus: is not all about feeding and energy homeostasis. Sleep. 2021 Apr 8:zsab083. doi: 10.1093/sleep/zsab083.

Freire C., Pho H, Bevans-Fonti S, Sennes LU, Polotsky VY. Intranasal leptin improves survival after opioid overdose in a mouse model. J Transl Med. 2021 Mar 31; 19(1):134. Doi: 10.1186/s12967-021-02803-8. PMID: 33789690.

Yeung BH-Y, Griffiths K, Berger L, Paudel O, Shin M-K, Rui L, Sham JSK, Polotsky VY, and Tang W-Y. Leptin Induces Epigenetic Regulation of Transient Receptor Potential Melastatin 7 in PC12 Cells. Am J Respir Cell Mol Biol.  2021 Aug;65(2):214-221. PMID: 33891828.

Editorial: Lingappan K. Does the Epigenome Hold Clues to Leptin-associated Hypertension in Obesity? Am J Respir Cell Mol Biol. 2021 Aug;65(2):132-133.

Shin M-K, Mitrut M, Gu C, Kim LJ, Yeung BHY, Lee R, Pham L, Tang W-Y, Sham JSK, Cui H, and Polotsky VY.  Pharmacological and Genetic Blockade of Trpm7 in the Carotid Body Treats Obesity-Induced Hypertension. Hypertension. 2021. Jul; 78(1):104-114. PMID: 33993722.

Duan D, Gu G, Polotsky VY, Jun JC, and Pham LV. Effects of Dinner Timing on Sleep Stage Distribution and EEG Power Spectrum in Healthy Volunteers. Nat Sci Sleep. 2021 May 14;13:601-612. PMID: 34017207 PMCID: PMC8131073.

Amorim MR, Dergacheva O, Fleury-Curado T, Pho H, Freire C, Mendelowitz D, Branco LGS, Polotsky VY. The effect of DREADD activation of leptin receptor positive neurons in the nucleus of the solitary tract on sleep disordered breathing. Int. J. Mol. Sci. 2021, 22, 6742. https://doi.org/10.3390/ijms22136742. PMID: 34201760.

Kim LJ, Shin M-K, Pho H, Tufik S, Andersen ML, Pham LV, and Polotsky VY. Leptin Receptor Blockade Attenuates Hypertension, but Does Not Affect Ventilatory Response to Hypoxia in a Model of Polygenic Obesity. Front. Physiol., 02 July 2021. 
https://doi.org/10.3389/fphys.2021.688375. PMID: 34276408

Sowho M, Schneider H, Jun J, MacCarrick G, Schwartz A, Pham L, Sgambati F, Lima J, Smith P, Polotsky V, Neptune E. D-dimer in Marfan Syndrome: Effect of Obstructive Sleep Apnea induced Blood Pressure Surges. Am J Physiol Heart Circ Physiol. 2022 Mar 11. doi: 10.1152/ajpheart.00004.2022. Online ahead of print. PMID: 3527576.

Gu C, Loube J, Lee R, Bevans-Fonti S, Wu TD, Barmine JH, Jun JC, McCormack MC, Hansel NN, Mitzner W, and Polotsky VY. Metformin Alleviates Airway Hyperresponsiveness in a Mouse Model of Diet-Induced Obesity. Front Physiol. 2022 Apr 29;13:883275. doi: 10.3389/fphys.2022.883275. eCollection 2022. PMID: 35574481.

Pho H, Amorim MR, Qiu Q, Shin MK, Kim LJ, Anokye-Danso F, Jun JJ, Ahima RS, Branco LGS, Kuhn DM, Mateika JH, and Polotsky VY.  The effect of brain serotonin deficiency on breathing is magnified by age. Physiol Rep. 2022 May;10(10):e15245. doi: 10.14814/phy2.15245. PMID: 35581741.

Kim LJ, Pho H, Pham LV, and Polotsky VY. Isocapnic CO2 administration stabilizes breathing and eliminates apneas during sleep in obese mice exposed to hypoxia. Sleep. 2023 Feb 8;46(2):zsac243. doi: 10.1093/sleep/zsac243. PMID: 36183293.

Kim LJ, Alexandre C, Pho H, Latremoliere A, Polotsky VY, and Pham LV. Diet-induced obesity leads to sleep fragmentation independently of the severity of sleep-disordered breathing. J Appl Physiol (1985). 2022 Dec 1;133(6):1284-1294. doi: 10.1152/japplphysiol.00386.2022. PMID: 36201322.

Kim LJ, Shin MK, Pho H, Tang WY, Hosamane N, Anokye-Danso F, Ahima RS, Sham JSK, Pham LV, and Polotsky VY.  TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies. J Physiol. 2022 Dec;600(23):5145-5162. doi: 10.1113/JP283678. PMID: 36214387.

Editorial: Zubieta-DeUrioste N and Wilson RJA. Beyond arterial blood gas sensing: the carotid body's TRP to broad physiological function.  J. Physiol. 2022. https://doi.org/10.1113/JP283940.

Freire C, Ramsey JD, Pho H, Kojima R, Kim LJ, Batrakova EV, Kabanov AV, and Polotsky VY. Leptin-loaded extracellular vesicles treat sleep-disordered breathing in obesity. Am J Respir Cell Mol Biol. 2022 Dec;67(6):720-723. doi: 10.1165/rcmb.2022-0229LE. PMID: 36454084.

Fleury Curado T, Pham L, Otvos T, Klopfer T, Freire C, Amorim MR, Nishimura Y, Sennes LU, Psoter KJ,  Abdelwahab M, Huang A, Dedhia R, Liu S, Capasso R, Oliven A, Polotsky V, Eisele D, Schwartz A. Changes in tongue morphology predict responses in pharyngeal patency to selective hypoglossal nerve stimulation. J Clin Sleep Med. 2023 Feb 2. doi: 10.5664/jcsm.10474. Online ahead of print. PMID: 36727502

Dergacheva O, Polotsky VY, Mendelowitz D. Oxytocin mediated excitation of hypoglossal motoneurons: implications for treating obstructive sleep apnea. Sleep. 2023 Feb 27;zsad009. doi: 10.1093/sleep/zsad009. Online ahead of print. PMID: 36846973

Osman A, Gu G, Kim DE, Duan D, Barron B, Pham LV, Polotsky VY, Jun JJ. Ketogenic diet acutely improves gas exchange and sleep apnoea in obesity hypoventilation syndrome: A non-randomized crossover study. Respirology. 2023 May 28. doi: 10.1111/resp.14526. Online ahead of print. dOI: 10.1111/resp.14526. PMID: 37246156.

Kim LJ, Pho H, Anokyo-Danso F, Ahima RS, Pham LV, and Polotsky VY. The effect of diet-induced obesity on sleep and breathing in female mice. Sleep. 2023 Jun 1;zsad158. doi: 10.1093/sleep/zsad158. Online ahead of print. PMID: 37262435.

Duan D, Perin J, Osman A, Sgambati F, Kim LJ, Pham LV, Polotsky VY, Jun JC. Effects of sex, age, and body mass index on serum bicarbonate. Front Sleep. 2023;2:1195823. doi: 10.3389/frsle.2023.1195823. PMID: 37736141.

Amorim MR, Wang X, Aung O, Bevans-Fonti S, Anokye-Danso F, Ribeiro C, Escobar J, Freire C, Pho H, Dergacheva O, Branco LGS, Ahima RS, Mendelowitz D, and Polotsky VY. Leptin signaling in the dorsomedial hypothalamus couples breathing and metabolism in obesity. Cell Rep. 2023 Nov 30;42(12):113512.doi: 10.1016/j.celrep.2023.113512. Online ahead of print. PMID: 38039129.

Singer ML, Shin MK, Kim LJ, Freire C, Aung O, Pho H, East JA, Sgambati FP, Latremoliere A, Pham LV, and Polotsky VY. The efficacy of intranasal leptin for opioid-induced respiratory depression depends on sex and obesity state. Front Physiol. 2023 Dec 13;14:1320151. doi: 10.3389/fphys.2023.1320151. eCollection 2023. PMID: 38162827.

Shin MK, Tang WY, Amorim MR, Sham JSK, and Polotsky VY. Carotid body denervation improves hyperglycemia in obese mice. J Appl Physiol (1985). 2024 Feb 1;136(2):233-243. doi: 10.1152/japplphysiol. 00215. 2023. PMID: 38126089.