Sowho M, Schneider H, Jun J, MacCarrick G, Schwartz A, Pham L, Sgambati F, Lima J, Smith P, Polotsky V, Neptune E. D-dimer in Marfan Syndrome: Effect of Obstructive Sleep Apnea induced Blood Pressure Surges. Am J Physiol Heart Circ Physiol. 2022 Mar 11. doi: 10.1152/ajpheart.00004.2022. Online ahead of print. PMID: 3527576.
Gu C, Loube J, Lee R, Bevans-Fonti S, Wu TD, Barmine JH, Jun JC, McCormack MC, Hansel NN, Mitzner W, and Polotsky VY. Metformin Alleviates Airway Hyperresponsiveness in a Mouse Model of Diet-Induced Obesity. Front Physiol. 2022 Apr 29;13:883275. doi: 10.3389/fphys.2022.883275. eCollection 2022. PMID: 35574481.
Pho H, Amorim MR, Qiu Q, Shin MK, Kim LJ, Anokye-Danso F, Jun JJ, Ahima RS, Branco LGS, Kuhn DM, Mateika JH, and Polotsky VY. The effect of brain serotonin deficiency on breathing is magnified by age. Physiol Rep. 2022 May;10(10):e15245. doi: 10.14814/phy2.15245. PMID: 35581741.
Kim LJ, Pho H, Pham LV, and Polotsky VY. Isocapnic CO2 administration stabilizes breathing and eliminates apneas during sleep in obese mice exposed to hypoxia. Sleep. 2023 Feb 8;46(2):zsac243. doi: 10.1093/sleep/zsac243. PMID: 36183293.
Kim LJ, Alexandre C, Pho H, Latremoliere A, Polotsky VY, and Pham LV. Diet-induced obesity leads to sleep fragmentation independently of the severity of sleep-disordered breathing. J Appl Physiol (1985). 2022 Dec 1;133(6):1284-1294. doi: 10.1152/japplphysiol.00386.2022. PMID: 36201322.
Kim LJ, Shin MK, Pho H, Tang WY, Hosamane N, Anokye-Danso F, Ahima RS, Sham JSK, Pham LV, and Polotsky VY. TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies. J Physiol. 2022 Dec;600(23):5145-5162. doi: 10.1113/JP283678. PMID: 36214387.
Editorial: Zubieta-DeUrioste N and Wilson RJA. Beyond arterial blood gas sensing: the carotid body's TRP to broad physiological function. J. Physiol. 2022. https://doi.org/10.1113/JP283940.
Freire C, Ramsey JD, Pho H, Kojima R, Kim LJ, Batrakova EV, Kabanov AV, and Polotsky VY. Leptin-loaded extracellular vesicles treat sleep-disordered breathing in obesity. Am J Respir Cell Mol Biol. 2022 Dec;67(6):720-723. doi: 10.1165/rcmb.2022-0229LE. PMID: 36454084.
Fleury Curado T, Pham L, Otvos T, Klopfer T, Freire C, Amorim MR, Nishimura Y, Sennes LU, Psoter KJ, Abdelwahab M, Huang A, Dedhia R, Liu S, Capasso R, Oliven A, Polotsky V, Eisele D, Schwartz A. Changes in tongue morphology predict responses in pharyngeal patency to selective hypoglossal nerve stimulation. J Clin Sleep Med. 2023 Feb 2. doi: 10.5664/jcsm.10474. Online ahead of print. PMID: 36727502
Dergacheva O, Polotsky VY, Mendelowitz D. Oxytocin mediated excitation of hypoglossal motoneurons: implications for treating obstructive sleep apnea. Sleep. 2023 Feb 27;zsad009. doi: 10.1093/sleep/zsad009. Online ahead of print. PMID: 36846973
Osman A, Gu G, Kim DE, Duan D, Barron B, Pham LV, Polotsky VY, Jun JJ. Ketogenic diet acutely improves gas exchange and sleep apnoea in obesity hypoventilation syndrome: A non-randomized crossover study. Respirology. 2023 May 28. doi: 10.1111/resp.14526. Online ahead of print. dOI: 10.1111/resp.14526. PMID: 37246156.
Kim LJ, Pho H, Anokyo-Danso F, Ahima RS, Pham LV, and Polotsky VY. The effect of diet-induced obesity on sleep and breathing in female mice. Sleep. 2023 Jun 1;zsad158. doi: 10.1093/sleep/zsad158. Online ahead of print. PMID: 37262435.
Duan D, Perin J, Osman A, Sgambati F, Kim LJ, Pham LV, Polotsky VY, Jun JC. Effects of sex, age, and body mass index on serum bicarbonate. Front Sleep. 2023;2:1195823. doi: 10.3389/frsle.2023.1195823. PMID: 37736141.
Amorim MR, Wang X, Aung O, Bevans-Fonti S, Anokye-Danso F, Ribeiro C, Escobar J, Freire C, Pho H, Dergacheva O, Branco LGS, Ahima RS, Mendelowitz D, and Polotsky VY. Leptin signaling in the dorsomedial hypothalamus couples breathing and metabolism in obesity. Cell Rep. 2023 Nov 30;42(12):113512.doi: 10.1016/j.celrep.2023.113512. Online ahead of print. PMID: 38039129.
Singer ML, Shin MK, Kim LJ, Freire C, Aung O, Pho H, East JA, Sgambati FP, Latremoliere A, Pham LV, and Polotsky VY. The efficacy of intranasal leptin for opioid-induced respiratory depression depends on sex and obesity state. Front Physiol. 2023 Dec 13;14:1320151. doi: 10.3389/fphys.2023.1320151. eCollection 2023. PMID: 38162827.
Shin MK, Tang WY, Amorim MR, Sham JSK, and Polotsky VY. Carotid body denervation improves hyperglycemia in obese mice. J Appl Physiol (1985). 2024 Feb 1;136(2):233-243. doi: 10.1152/japplphysiol. 00215. 2023. PMID: 38126089.
Shin MK, Kim LJ, Davaanyam D, Amorim MR, Lee SM, Tang WY, Polotsky VY. Leptin receptor downregulation in the carotid body treats obesity-induced hypertension. J Neurophysiol. 2025 Mar 1;133(3):892-903. doi: 10.1152/jn.00133.2024. Epub 2025 Feb 4. PMID: 39903168.
Wang X, Ribeiro C, Nilsson A, Escobar JB, Alber BR, Bethea JR, Polotsky VY, Kay MW, Schunke K, Mendelowitz D. Oxytocin Receptor Expression and Activation in Parasympathetic Brainstem Cardiac Vagal Neurons. bioRxiv [Preprint]. 2025 Mar 20:2025.03.19.644204. doi: 10.1101/2025.03.19.644204.
Amorim MR, Williams NR, Aung O, Alexis Ruiz M, Anokye-Danso F, de Deus JL, Xiong J, Dergacheva O, Bevans-Fonti S, Lee SM, Berger JS, Wu MN, Ahima RS, Mendelowitz D, and Polotsky VY. Targeting melanocortin 4 receptor to treat sleep disordered breathing in mice. J Clin Invest. 2025 Apr 15:e177823. doi: 10.1172/JCI177823. Online ahead of print. PMID: 40232848.
Cheung EC, Escobar JB, Alber BR, Ribeiro C, Abdullah I, Kowalik G, Rodriguez J, Harral G, Melkie M, Gill A, Ketzenberger JT, Bethea J, Polotsky VY, Jain V, Schunke K, Kay MW, Mendelowitz D. Chronic intermittent hypoxia-mediated cognitive dysfunction in ovariectomized rats. Exp Physiol. 2025 May 19. doi: 10.1113/EP092018. Online ahead of print. PMID: 40388406
Sun B, Shin MK, Qin M, Anderson CF, Xu T, Yang J, Sklar C, Polotsky VY, Cui H. Drug-Inspired Design of Supramolecular Polymers for Enhanced Drug Loading and Sustained Therapeutic Release. ACS Nano. 2025 Jun 30. doi: 10.1021/acsnano.5c02462. Online ahead of print. PMID: 40586378.
Wang X, Ribeiro C, Nilsson A, Escobar JB, Alber BR, Bethea JR, Polotsky VY, Kay MW, Schunke K, Mendelowitz D. Oxytocin Receptor Expression and Activation in Parasympathetic Brainstem Cardiac Vagal Neurons eNeuro. 2025 Aug 6:ENEURO.0204-25.2025. doi: 10.1523/ENEURO.0204-25.2025. Online ahead of print. PMID: 40769582
Roy A, Shin MK, Davaanyam D, Williams N, Lee SM, Tang WY, and Polotsky VY. Diet-induced obesity in mice increases carotid body chemosensitivity via the leptin-TRPM7 pathway. J Physiol. 2025 Aug 10. doi: 10.1113/JP288722. Online ahead of print. PMID: 40784675.
Escobar JB, Wainwright J, Wang X, Dergacheva O, Kay MW, Bethea JR, Jain V, Polotsky VY, Mendelowitz D. Oxytocin treats respiratory depression and reduces mortality from fentanyl and the combination of xylazine-fentanyl. bioRxiv [Preprint]. 2026 Feb 24:2026.02.23.702914. doi:10.64898/2026.02.23.702914. PMID: 41809014 PMCID: PMC12970325 DOI: 10.64898/2026.02.23.702914.
Shin MK, Roy A, Padel O, Gudapati S, Sham JS, Tang WY, Polotsky VY. Epigenetic Silencing of Carotid Body TRPM7 Attenuates Hypertension in Obese Mice. bioRxiv [Preprint]. 2026 Mar 7:2026.03.05.709322. doi: 10.64898/2026.03.05.709322. PMID: 41867860 PMCID: PMC13001396.
Pham LV, Duan D, Badami V, Perin J, Potocki M, Polotsky VY, Jun JC. Propranolol mitigates sleep apnea-related cardiac responses during CPAP withdrawal: a randomized placebo-controlled cross-over clinical study. Sleep Breath. 2026 Mar 11;30(1):88. doi: 10.1007/s11325-026-03645-8.